In eukaryotes, folate metabolism is compartmentalized between the cytoplasm and organelles. The folate pathways of mitochondria are adapted to serve the metabolism of the organism. In yeast, mitochondria support cytoplasmic purine synthesis through the generation of formate. This pathway is important but not essential for survival, consistent with the flexibility of yeast metabolism. In plants, the mitochondrial pathways support photorespiration by generating serine from glycine. This pathway is essential under photosynthetic conditions and the enzyme expression varies with photosynthetic activity. In (...) mammals, the expression of the mitochondrial enzymes varies in tissues and during development. In embryos, mitochondria supply formate and glycine for purine synthesis, a process essential for survival; in adult tissues, flux through mitochondria can favor serine production. The differences in the folate pathways of mitochondria depending on species, tissues and developmental stages, profoundly alter the nature of their metabolic contribution. BioEssays 28: 595–605, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

The general conceit of Schiller’s aesthetic education is that our experiences with art and beauty set us free from internal and external constraints and allow us to embrace our full humanity as rational and sensuous beings. Experiencing the aesthetic, or the play impulse, puts one in a state of aesthetic determinacy—or rather indeterminacy—that Schiller calls the highest sense of freedom, aesthetic freedom. Gail K. Hart examines Anthony Burgess’s A Clockwork Orange as an example of what Schillerian aesthetic education might look (...) like in practice. Though it represents a distortion of Schiller’s aesthetic education, Hart argues that it also reveals an ineradicable element of coercion in aesthetic education. I argue that Burgess’s Ludovico Technique leaves out a key element of Schiller’s conception of aesthetic cultivation—play—and that Hart’s analysis of Schiller’s work likewise lacks a robust analysis of his notion of play. I argue that, when Schiller’s account of the play impulse is taken seriously as a necessary condition for aesthetic cultivation to take place, coercion is by definition made impossible. Aesthetic play is accomplished by the mutual destruction of physical and moral determinations, and this mutual erasure leads to a higher and more expansive freedom. External constraints and coercion cannot induce the aesthetic state, so aesthetic education as Schiller presents it in On the Aesthetic Education of Man cannot contain the element of coercion Hart suspects. (shrink)

When Congress passed the 19th Amendment in 1919 granting women voting rights, 13 western states had already adopted woman suffrage. Only 2 states outside the West had done so. Using event history analysis, the authors investigate why woman suffrage came early to the western states. Alan Grimes's hypotheses, that native-born, western men were willing to give women the vote to remedy western social problems and to increase the number of women in the region, receive little support in our analysis. Rather, (...) this study finds that woman suffrage came to the West because of the mobilization of the western suffrage movements and because of political and gendered opportunities existing in that region. (shrink)

Based on studies with infants, we expand on Stoffregen & Bardy's explanation of perceptual motor errors, given the global array. Information pick-up from the global array is not sufficient without adequate exploratory movements and learning to support perceptually guided activity.

Cross‐situational word learning (XSWL) tasks present multiple words and candidate referents within a learning trial such that word–referent pairings can be inferred only across trials. Adults encode fine phonological detail when two words and candidate referents are presented in each learning trial (2 × 2 scenario; Escudero, Mulak, & Vlach, ). To test the relationship between XSWL task difficulty and phonological encoding, we examined XSWL of words differing by one vowel or consonant across degrees of within‐learning trial ambiguity (1 × (...) 1 to 4 × 4). Word identification was assessed alongside three distractors. Adults finely encoded words via XSWL: Learning occurred in all conditions, though accuracy decreased across the 1 × 1 to 3 × 3 conditions. Accuracy was highest for the 1 × 1 condition, suggesting fast‐mapping is a stronger learning strategy here. Accuracy was higher for consonant than vowel set targets, and having more distractors from the same set mitigated identification of vowel set targets only, suggesting possible stronger encoding of consonants than vowels. (shrink)

Contemporary virtue ethicists widely accept thethesis that a virtuous agent''s feelings shouldbe in harmony with her judgments about what sheshould do and that she should find virtuousaction easy and pleasant. Conflict between anagent''s feelings and her actions, by contrast,is thought to indicate mere continence – amoral deficiency. This ``harmony thesis'''' isgenerally taken to be a fundamental element ofAristotelian virtue ethics.I argue that the harmony thesis, understoodthis way, is mistaken, because there areoccasions where a virtuous agent will findright action painful and (...) difficult. What thismeans is that the generally accepteddistinction between continence and virtue isunsupportable. This conclusion affects severalwell-known accounts of virtuous action,including those of Philippa Foot and JohnMcDowell. A closer look at Aristotle, however, providesanother way of distinguishing betweencontinence and virtue, based in hiscategorization of goods as noble or base. Iargue that virtue is exhibited when anagent''s feelings harmonize with his correctjudgments of value, while discrepancies betweenfeelings and correct judgments of valueindicate continence. This understanding ofcontinence and virtue enables us to accommodatethe problem cases I raise. (shrink)

Scholars of hermeneutics have recently taken up the task of elucidating Gadamer’s ethics by studying his work on the structure of understanding and human experience. This article seeks to contribute to that scholarship through an examination of Gadamer’s aesthetics. I suggest that Gadamer’s notions of play and aesthetic non-differentiation provide further resources for understanding Gadamer’s hermeneutic ethics as an ethics of non-differentiation, i.e., a unification of theory and practice (understanding and application). For Gadamer, an understanding of the good is its (...) enactment in the context of the dialogical play we find ourselves engaged in with others. Furthermore, Gadamer’s identification of aesthetic non-differentiation with play reveals that his ethics aims not only to unify theory and practice but also to unite participants in the ethical play as intersubjective elements of a shared experience. Retrieving the ethical import of Gadamer’s aesthetics also helps to unfold Gadamer’s suggestion that hermeneutics itself is an ethical enterprise. (shrink)

Scholars of hermeneutics have recently taken up the task of elucidating Gadamer’s ethics by studying his work on the structure of understanding and human experience. This article seeks to contribute to that scholarship through an examination of Gadamer’s aesthetics. I suggest that Gadamer’s notions of play and aesthetic non-differentiation provide further resources for understanding Gadamer’s hermeneutic ethics as an ethics of non-differentiation, i.e., a unification of theory and practice. For Gadamer, an understanding of the good is its enactment in the (...) context of the dialogical play we find ourselves engaged in with others. Furthermore, Gadamer’s identification of aesthetic non-differentiation with play reveals that his ethics aims not only to unify theory and practice but also to unite participants in the ethical play as intersubjective elements of a shared experience. Retrieving the ethical import of Gadamer’s aesthetics also helps to unfold Gadamer’s suggestion that hermeneutics itself is an ethical enterprise. (shrink)

Schools are ideal settings for implementing multi-component programs to prevent and control childhood obesity. Thoughtful improvements to proven strategies, coupled with careful evaluation, can contribute to accumulation of evidence needed to design and implement the next generation of optimal interventions.

The obesity epidemic among children and adolescents in the United States continues to worsen. The most recent analysis of data from the National Health and Nutrition Examination Survey showed that the prevalence of overweight among children and adolescents – defined as a Body Mass Index at or above the 95th percentile on gender-specific BMI-for-age growth charts developed by the Centers for Disease Control and Prevention – increased significantly between 1999-2000 and 2003-2004. Over this period, the prevalence of overweight among children (...) and adolescents aged 2-19 increased 23% – from 13.9% to 17.1%. In 2003-2004, 18.8% of children aged 6-11 and 17.4% of adolescents aged 12-19 were overweight. Roughly comparable proportions of each age group were considered to be at risk of becoming overweight. (shrink)

Darrel E. Christensen presented the following paper to the Charles Sanders Peirce Society meeting held on October 5–7, 1978, at Bloomington, Indiana.

A critique of Whitehead’s conccpt of God from the standpoint of absolute idealism in general and of Hegel and Whitehead’s relation to Hegel in particular.

A tendency has been discernible in recent decades, more marked within the Anglo-American philosophical tradition, to regard a turn or a return to Hegel as a reverie for rumination following a flight from “critical principles” which had been thought secure but which have failed. A result has been that the critical dimensions of his thought, resting upon its hard logical core, the principle of the spekulativen Satz, has very frequently been deemphasized or entirely overlooked.

The contemporary crisis of authority is in part to be understood as a reflection of certain philosophical doctrines of the recent past. The emotivist and the existentialist theories of value language, which remain most prevalent today, have contributed to a disposition to regard only the informed decision of the individual as authentic, and to construe moral judgments as without fault except when not fully informed or not one’s own. Where an individual differs from constituted authority, following either of these views, (...) there is no way in which it can be said that either is in error. The philosophical solution to the present crisis must lie in a realistic theory of empirical value knowledge. (shrink)

Ivor Leclerc, citing the following passage from Adventures of Ideas, interprets Whitehead’s metaphysics as an explication of the concept of an actual entity construed as a “complete fact”.

_Repair of the Soul_ examines transformation from the perspective of Jewish mysticism and psychoanalysis, addressing the question of how one achieves self-understanding that leads not only to insight but also to meaningful change. In this beautifully written and thought-provoking book, Karen Starr draws upon a contemporary relational approach to psychoanalysis to explore the spiritual dimension of psychic change within the context of the psychoanalytic relationship. Influenced by the work of Lewis Aron, Steven Mitchell and other relational theorists, and drawing (...) upon contemporary scholarship in the field of Jewish studies, Starr brings the ideas of the Kabbalah, the ancient Jewish mystical tradition, into dialogue with modern psychoanalytic thought. _Repair of the Soul_ provides a scholarly integration of several kabbalistic and psychoanalytic themes relating to transformation, including faith, surrender, authenticity, and mutuality, as well as a unique exploration of the relationship of the individual to the universal. Starr uses the Kabbalah’s metaphors as a vivid framework with which to illuminate the experience of transformation in psychoanalytic process, and to explore the evolving view of the psychoanalytic relationship as one in which both parties - the analyst as well as the patient - are transformed. (shrink)

The Oxford Handbook of Media Psychology explores facets of human behaviour, thoughts, and feelings experienced in the context of media use and creation.

The promotion of human rights, the punishment of crimes against humanity, the use of force with respect to humanitarian intervention: these are some of the complex issues facing governments in recent years. The contributors to this book offer a theoretical and empirical approach to these issues. Three leading normative theorists first explore what an 'ethical foreign policy' means. Four contributors then look at potential or actual instruments of ethical foreign policy-making: the export of democracy, non-governmental organisations, the International Criminal Court, (...) and bottom-up public pressure on governments. Finally, three case studies examine more closely developments in the foreign policies of the US, the UK, and the European Union, to assess the difficulties raised by the incorporation of ethical considerations into foreign policy. (shrink)

The education of future generations of citizens is the one common theme that connects otherwise culturally, linguistically, ethnically, and politically diverse communities and countries in an increasingly global society. Social systems foster socially toxic environments, instilling a culture of fear while ignoring the importance of preparing youth for advanced citizenship in a global civil society. The author examines the role of education in relation to global events and explores the purposes of education in meeting the needs of tomorrow's children in (...) an evolving, global society. Specifically, education is examined in relation to creating a safe and socially just society. (shrink)

It has become a truism in discussions of Imperialist literature to state that the British empire was, in a very significant way, a textual exercise. Empire was simultaneously created and perpetuated through a proliferation of texts driven significantly by a desire for what Thomas Richards describes as “one great system of knowledge.” The project of assembling this system assumed that all of the “alien” knowledges that it drew upon could be easily assimilated into existing, “universal” epistemological categories. This belief in (...) “one great system” assumed that knowledges from far-flung outposts of empire could, through careful categorization and control, be made to reinforce, rather than threaten, the authority of imperial epistemic rule. But this movement into “new” epistemic as well as physical spaces opened up the disruptive possibility for and encounter with Foucault’s “insurrection of subjugated knowledges.” In the Imperial Gothic stories discussed here, the space between “knowing all there is to know” and the inherent unknowability of the “Other” is played out through representations of failures of classification and anxieties about the limits of knowledge. These anxieties are articulated through what is arguably one of the most heavily regulated signifiers of scientific progress at the turn of the century: the body. In an age that was preoccupied with bodies as spectacles that signified everything from criminal behaviour, psychological disorder, moral standing and racial categorization, the mutable, unclassifiable body functions as a signifier that mediates between imperial fantasies of control and definition and fin-de-siècle anxieties of dissolution and degeneration. In Imperial Gothic fiction these fears appear as a series of complex explorations of the ways in which the gap between the known and the unknown can be charted on and through a monstrous body that moves outside of stable classification. (shrink)

Devoted to making available, in English, contributions to philosophical comprehension originating in German, Contemporary German Philosophy will be a yearbook following volumes reviewing the 1960-80 period. CGP's aim is in no sense to displace the German language as a medium for philosophical discourse, but rather to provide for the reader who is more at home in English some points of access to such of the more pivotal recent and contemporary contributions originating in German as can lend themselves to translation. In (...) the selection of German-language articles for translation, some preference is given to authors whose work for the most part has not yet appeared in English. Original articles by German scholars also will be featured, and there will be reviews and comments by a worldwide body of scholars concerned with German philosophical traditions. CGP is open to the full range of philosophical interests and orientations to which philosophy in the German language and tradition contributes. It is open as well to items which consider the bearings of insights within such allied fields as mathematics, political science, historiography, and linguistics upon philosophical issues. The term "contemporary" is intended to refer, not to any particular style of doing philosophy, but to philosophical literature of recent origin. (shrink)

A collaboration has been arranged for the preparation and publication in three dual-language volumes within the Hegel series presently in preparation by Fr. Frommanns Verlag of new critical editions of Hegel’s 1821 Lectures on the Philosophy of Religion, to be included in one volume with the up to now unpublished first form of his Encyclopedia, and Hegel’s 1824 Lectures on the Philosophy of Religion, in two volumes. The new German editions are to be prepared by Professor Dr. K.-H. Ilting. The (...) English translations are to be prepared by Professor Darrel E. Christensen. The anticipation is that the first of these editions will appear some time in 1973. (shrink)

Cross-situational statistical learning of words involves tracking co-occurrences of auditory words and objects across time to infer word-referent mappings. Previous research has demonstrated that learners can infer referents across sets of very phonologically distinct words, but it remains unknown whether learners can encode fine phonological differences during cross-situational statistical learning. This study examined learners’ cross-situational statistical learning of minimal pairs that differed on one consonant segment, minimal pairs that differed on one vowel segment, and non-minimal pairs that differed on two (...) or three segments. Learners performed above chance for all pairs, but performed worse on vowel minimal pairs than on consonant minimal pairs or non-minimal pairs. These findings demonstrate that learners can encode fine phonetic detail while tracking word-referent co-occurrence probabilities, but they suggest that phonological encoding may be weaker for vowels than for consonants. (shrink)

Following the Introduction, the essays to be listed, each with a reply by Errol E. Harris, comprise the principal content. B. Blanshard, “Harris on Internal Relations”; G.R. Lucas, Jr., “Science and Teleological Explanations”; J.E. Smith, “Harris’ Commentary on Hegel’s Logic”; G. Rinaldi, “The Identity of Thought and Being in Harris’ Interpretation of Hegel’s Logic”: T. Rockmore, “System and History: Harris on Hegel’s Logic”; R. Hepburn, “The Problem of Evil”; W. H. Walsh, “Hegel on Morality”; W.N.A. Klever, “The Properties of the (...) Intellect”; P. Muller, “The pons asinorum in Philosophy”; Wm. Earle, “The Evanescent Authority of Philosophy.”. (shrink)